Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 15/20 | 0.71 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.38 |
| ▸ | AOC1 | P19801 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5878563 | 0.83 | SLC6A4 (0.67) | SLC6A4HTR2AKCNH2SLC6A2SLC6A3 | |
| SCHEMBL5878517 | 0.83 | SLC6A4 (1.00) | SLC6A4HTR2AKCNH2SLC6A2SLC6A3 | |
| SCHEMBL5878706 | 0.79 | SLC6A4 (0.62) | SLC6A4HTR2AKCNH2SLC6A2SLC6A3 | |
| SCHEMBL5878691 | 0.74 | SLC6A4 (0.56) | SLC6A4HTR2AKCNH2SLC6A2SLC6A3 | |
| SCHEMBL5878607 | 0.74 | SLC6A4 (0.80) | SLC6A4HTR2AKCNH2SLC6A2SLC6A3 | |
| SCHEMBL6152181 | 0.73 | SLC6A4 (0.72) | SLC6A4HTR2AKCNH2SLC6A2SLC6A3 | |
| SCHEMBL31119316 | 0.72 | CYP1A2 (0.51) | SLC6A4SLC6A2SLC6A3AOC3AOC1 | |
| SCHEMBL4483018 | 0.72 | CYP1A2 (0.51) | SLC6A4SLC6A2SLC6A3AOC3AOC1 | |
| SCHEMBL11485483 | 0.71 | SLC6A4 (0.51) | SLC6A4HTR2AKCNH2SLC6A2SLC6A3 | |
| SCHEMBL6160314 | 0.71 | SLC6A4 (0.46) | SLC6A4HTR2AKCNH2SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377550-B9 | PHENYL HETEROCYCLYL ETHER DERIVATIVES AS SEROTONIN RE-UPTAKE INHIBITORS | PFIZER LTD (GB) | 2005-11-23 | — | — | EP | disclosed |
| EP-1377550-B1 | PHENYL HETEROCYCLYL ETHER DERIVATIVES AS SEROTONIN RE-UPTAKE INHIBITORS | PFIZER LTD (GB) | 2004-11-03 | — | — | EP | disclosed |