Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 0.54 |
| ▸ | RAF1 | P04049 | 4/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.41 |
| ▸ | TNF | P01375 | 3/20 | 0.40 |
| ▸ | ABL1 | P00519 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | LYN | P07948 | 2/20 | 0.40 |
| ▸ | BRAF | P15056 | 2/20 | 0.40 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.40 |
| ▸ | EPHA3 | P29320 | 2/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.40 |
| ▸ | CIT | O14578 | 1/20 | 0.40 |
| ▸ | MUSK | O15146 | 1/20 | 0.40 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.40 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.40 |
| ▸ | STK10 | O94804 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6163426 | 0.84 | MAPK14 (0.59) | MAPK14RAF1MAPK13MAPK12MAPK11 | |
| SCHEMBL6165444 | 0.83 | MAPK14 (0.47) | MAPK14RAF1MAPK13MAPK12MAPK11 | |
| SCHEMBL6163007 | 0.82 | RAF1 (0.51) | MAPK14RAF1MAPK13MAPK12MAPK11 | |
| SCHEMBL6163450 | 0.81 | MAPK14 (0.68) | MAPK14RAF1MAPK13MAPK12MAPK11 | |
| SCHEMBL6165331 | 0.81 | MAPK14 (0.54) | MAPK14RAF1MAPK13MAPK12MAPK11 | |
| SCHEMBL5619346 | 0.79 | MAPK14 (0.48) | MAPK14RAF1MAPK13MAPK12MAPK11 | |
| SCHEMBL294693 | 0.74 | MAPK14 (0.72) | MAPK14RAF1MAPK13MAPK12MAPK11 | |
| SCHEMBL6162657 | 0.74 | MAPK14 (0.56) | MAPK14RAF1MAPK13MAPK12MAPK11 | |
| SCHEMBL6162311 | 0.73 | MAPK14 (0.58) | MAPK14RAF1MAPK13MAPK12MAPK11 | |
| SCHEMBL6164974 | 0.73 | MAPK14 (0.67) | MAPK14RAF1MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1163236-B1 | AROMATIC HETEROCYCLIC COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMA (US) | 2005-11-09 | — | — | EP | disclosed |
| US-6476023-B1 | Aromatic heterocyclic compounds as anti-inflammatory agents | BOEHRINGEN INGELHEIM PHARMACEUTICALS, INC. | 2002-11-05 | — | — | US | disclosed |
| US-6297381-B1 | INHIBIT THE RELEASE OF INFLAMMATORY CYTOKINES SUCH AS INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR, UREAS OR THIOUREAS SUBSTITUTED BY A PYRROLE OR THIOPHENE | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2001-10-02 | — | — | US | disclosed |