Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 16/20 | 0.63 |
| ▸ | KDR | P35968 | 11/20 | 0.63 |
| ▸ | CSK | P41240 | 2/20 | 0.63 |
| ▸ | TEK | Q02763 | 2/20 | 0.63 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.55 |
| ▸ | EGFR | P00533 | 4/20 | 0.53 |
| ▸ | CIT | O14578 | 1/20 | 0.52 |
| ▸ | GAK | O14976 | 1/20 | 0.52 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.52 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.52 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.52 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.52 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.52 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.52 |
| ▸ | STK17B | O94768 | 1/20 | 0.52 |
| ▸ | STK10 | O94804 | 1/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.52 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6167015 | 0.99 | SRC (0.63) | SRCKDRCSKTEKEPHB4 | |
| SCHEMBL4023995 | 0.93 | SRC (0.72) | SRCKDRCSKTEKEPHB4 | |
| SCHEMBL4031671 | 0.91 | SRC (0.69) | SRCKDRCSKTEKEPHB4 | |
| SCHEMBL6167012 | 0.90 | SRC (0.68) | SRCKDRCSKTEKEPHB4 | |
| SCHEMBL4032303 | 0.90 | SRC (0.66) | SRCKDRCSKTEKEPHB4 | |
| SCHEMBL4022854 | 0.89 | SRC (0.68) | SRCKDRCSKTEKEPHB4 | |
| SCHEMBL4025065 | 0.88 | SRC (0.69) | SRCKDRCSKTEKEPHB4 | |
| SCHEMBL4021199 | 0.88 | SRC (0.68) | SRCKDRCSKTEKEPHB4 | |
| SCHEMBL4024497 | 0.88 | SRC (0.70) | SRCKDRCSKTEKEPHB4 | |
| SCHEMBL4024097 | 0.87 | SRC (0.68) | SRCKDRCSKTEKEPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1528925-A1 | QUINAZOLINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER | Astrazeneca AB (SE) | 2005-05-11 | — | — | EP | disclosed |
| WO-2004004732-A1 | QUINAZOLINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2004-01-15 | — | — | WO | disclosed |