Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 11/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 11/20 | 0.43 |
| ▸ | MERTK | Q12866 | 2/20 | 0.37 |
| ▸ | EP300 | Q09472 | 4/20 | 0.37 |
| ▸ | CCR3 | P51677 | 1/20 | 0.36 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.35 |
| ▸ | PTGIR | P43119 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4708697 | 0.94 | BRD4 (0.46) | PDE4BBRD4CREBBPMERTKEP300 | |
| SCHEMBL4708743 | 0.92 | PDE4B (0.49) | PDE4BBRD4CREBBPMERTKPTGIR | |
| SCHEMBL4708332 | 0.87 | PDE4B (0.46) | PDE4BBRD4CREBBPEP300CCR3 | |
| SCHEMBL4896402 | 0.84 | PDE4A (0.47) | PDE4BBRD4CREBBPEP300PTGIR | |
| SCHEMBL4705775 | 0.83 | PDE4B (0.58) | PDE4BCSNK1ECSNK1D | |
| SCHEMBL4706429 | 0.83 | PDE4B (0.49) | PDE4BBRD4CREBBPMERTKPTGIR | |
| SCHEMBL4708371 | 0.82 | PDE4B (0.54) | PDE4BBRD4CREBBPEP300PTGIR | |
| SCHEMBL4707908 | 0.82 | PDE4B (0.61) | PDE4BBRD4CREBBPEP300PTGIR | |
| SCHEMBL4707445 | 0.82 | PDE4B (0.62) | PDE4BBRD4CREBBP | |
| SCHEMBL4707025 | 0.81 | PDE4B (0.52) | PDE4BBRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1503992-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AS PDE4 INHIBITORS | Almirall Prodesfarma, S.A. (ES) | 2005-02-09 | — | — | EP | disclosed |
| WO-2003097613-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AS PDE4 INHIBITORS | ALMIRALL PRODESFARMA SA (ES) | 2003-11-27 | — | — | WO | disclosed |