Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 12/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 12/20 | 0.46 |
| ▸ | P2RY12 | Q9H244 | 8/20 | 0.46 |
| ▸ | PDE2A | O00408 | 6/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | IDH1 | O75874 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5417970 | 0.97 | PDE3B (0.48) | PDE3BPDE3AP2RY12PDE2APPARA | |
| SCHEMBL5426529 | 0.94 | PDE3B (0.47) | PDE3BPDE3AP2RY12PDE2APPARA | |
| SCHEMBL5420262 | 0.92 | PDE3B (0.46) | PDE3BPDE3AP2RY12PDE2APPARA | |
| SCHEMBL6369472 | 0.90 | PDE3B (0.46) | PDE3BPDE3AP2RY12PDE2APPARA | |
| SCHEMBL6169099 | 0.88 | PDE3B (0.45) | PDE3BPDE3AP2RY12PDE2APPARA | |
| SCHEMBL6168387 | 0.86 | PDE3B (0.51) | PDE3BPDE3AP2RY12PDE2ALTB4R | |
| SCHEMBL5422071 | 0.84 | PDE3B (0.47) | PDE3BPDE3AP2RY12PDE2APPARA | |
| SCHEMBL5481606 | 0.84 | PDE3B (0.46) | PDE3BPDE3AP2RY12PDE2APPARA | |
| SCHEMBL5410449 | 0.83 | PDE3B (0.46) | PDE3BPDE3AP2RY12PDE2APPARA | |
| SCHEMBL5409690 | 0.83 | PDE3B (0.51) | PDE3BPDE3AP2RY12PDE2APPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1404656-B9 | BENZIMIDAZOLE DERIVATIVES FOR TREATING MICROGLIA-ACTIVATION ASSOCIATED DISEASES SUCH AS INFLAMMATORY, ALLERGIC, INFECTIOUS OR AUTOIMMUNE DISEASES | SCHERING AG (DE) | 2005-10-19 | — | — | EP | claimed |
| EP-1404656-B1 | BENZIMIDAZOLE DERIVATIVES FOR TREATING MICROGLIA-ACTIVATION ASSOCIATED DISEASES SUCH AS INFLAMMATORY, ALLERGIC, INFECTIOUS OR AUTOIMMUNE DISEASES | SCHERING AG (DE) | 2005-05-18 | — | — | EP | claimed |