Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 6/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.35 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6176631 | 0.87 | MCL1 (0.44) | MCL1KCNH2AKR1B1AHRADORA3 | |
| SCHEMBL4453848 | 0.86 | MCL1 (0.40) | MCL1KCNH2AKR1B1AHRADORA3 | |
| SCHEMBL4449406 | 0.82 | MCL1 (0.41) | MCL1KCNH2AKR1B1AHRADORA3 | |
| SCHEMBL4462839 | 0.77 | AKR1B1 (0.60) | MCL1KCNH2AKR1B1ADORA3KMT2A | |
| SCHEMBL5263709 | 0.70 | AKR1B1 (0.40) | KCNH2AKR1B1AHRKMT2AALDH1A1 | |
| SCHEMBL14409919 | 0.67 | MCL1 (0.59) | MCL1KCNH2AKR1B1AHRADORA3 | |
| SCHEMBL25824628 | 0.65 | MCL1 (0.56) | MCL1KCNH2AKR1B1AHRADORA3 | |
| SCHEMBL4449382 | 0.65 | MCL1 (0.56) | MCL1KCNH2AKR1B1AHRADORA3 | |
| SCHEMBL12248491 | 0.62 | MCL1 (0.53) | MCL1KCNH2AKR1B1AHRADORA3 | |
| SCHEMBL3684433 | 0.62 | MCL1 (0.56) | MCL1KCNH2AKR1B1AHRADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463725-B1 | PROCESS AND INTERMEDIATES FOR PYRIDAZINONE ANTIDIABETIC AGENTS | PFIZER PROD INC (US) | 2005-08-17 | — | — | EP | disclosed |
| EP-1463725-A1 | PROCESS AND INTERMEDIATES FOR PYRIDAZINONE ANTIDIABETIC AGENTS | Pfizer Products Inc. (US) | 2004-10-06 | — | — | EP | disclosed |
| US-6759534-B2 | REACTING BENZOFURAN DERIVATIVE WITH ORGANOLITHIUM COMPOUND IN PRESENCE OF SULFUR SOURCE; REACTING WITH DICHLOROPYRIDAZINE DERIVATIVE, REACTING WITH ALKALINE ALKOXIDE IN ALKANOL; REACTING WITH MINERAL ACID, OXIDATION | PFIZER INC. | 2004-07-06 | — | — | US | disclosed |
| US-20030162969-A1 | Process and intermediates for pyridazinone antidiabetic agents | TOM NORMA J (US) | 2003-08-28 | — | — | US | disclosed |
| WO-2003057691-A1 | PROCESS AND INTERMEDIATES FOR PYRIDAZINONE ANTIDIABETIC AGENTS | PFIZER PRODUCTS INC. (US) | 2003-07-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030162969-A1 | Process and intermediates for pyridazinone antidiabetic agents | ALDOA, AKR1B1, DPYD | MCL1 4399/4885KCNH2 835/4885AKR1B1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.