Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | TOP2A | P11388 | 9/20 | 0.45 |
| ▸ | TOP2B | Q02880 | 9/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | ALB | P02768 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | TUBB | P07437 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6167582 | 1.00 | KDM4E (0.54) | KDM4ESMN1; SMN2CYP1A2TOP2ATOP2B | |
| SCHEMBL29473541 | 0.88 | KDM4E (0.52) | KDM4ESMN1; SMN2CYP1A2TOP2ATOP2B | |
| SCHEMBL4717918 | 0.88 | KDM4E (0.55) | KDM4ESMN1; SMN2CYP1A2TOP2ATOP2B | |
| SCHEMBL4714327 | 0.88 | KDM4E (0.52) | KDM4ESMN1; SMN2CYP1A2TOP2ATOP2B | |
| SCHEMBL4717920 | 0.88 | KDM4E (0.55) | KDM4ESMN1; SMN2CYP1A2TOP2ATOP2B | |
| SCHEMBL4714330 | 0.88 | KDM4E (0.52) | KDM4ESMN1; SMN2CYP1A2TOP2ATOP2B | |
| SCHEMBL500455 | 0.85 | TOP2A (0.53) | KDM4ESMN1; SMN2CYP1A2TOP2ATOP2B | |
| SCHEMBL9096661 | 0.85 | TOP2A (0.53) | KDM4ESMN1; SMN2CYP1A2TOP2ATOP2B | |
| SCHEMBL7607382 | 0.85 | TOP2A (0.53) | KDM4ESMN1; SMN2CYP1A2TOP2ATOP2B | |
| SCHEMBL4713048 | 0.84 | KDM4E (0.52) | KDM4ESMN1; SMN2CYP1A2TOP2ATOP2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1134219-B1 | CYCLOALKYL-SUBSTITUTED AMINOMETHYLPYRROLIDINE DERIVATIVES | DAIICHI SEIYAKU CO (JP) | 2005-06-15 | — | — | EP | disclosed |