Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 18/20 | 0.78 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | CX3CR1 | P49238 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL489716 | 0.88 | CXCR2 (1.00) | CXCR2HTR1BCX3CR1 | |
| SCHEMBL489715 | 0.88 | CXCR2 (1.00) | CXCR2HTR1BCX3CR1 | |
| SCHEMBL489705 | 0.79 | CXCR2 (1.00) | CXCR2CXCR1 | |
| SCHEMBL489733 | 0.77 | CXCR2 (0.80) | CXCR2HTR1BCX3CR1 | |
| SCHEMBL10205335 | 0.77 | CXCR2 (0.80) | CXCR2HTR1BCX3CR1 | |
| SCHEMBL1487024 | 0.76 | CXCR2 (0.76) | CXCR2CXCR1 | |
| SCHEMBL1486987 | 0.76 | CXCR2 (0.71) | CXCR2CXCR1SCN9A | |
| SCHEMBL1487023 | 0.75 | CXCR2 (0.71) | CXCR2CXCR1SCN9A | |
| SCHEMBL1487079 | 0.74 | CXCR2 (0.69) | CXCR2CXCR1SCN9A | |
| SCHEMBL1487193 | 0.73 | CXCR2 (0.70) | CXCR2CXCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1527051-A1 | PYRIMIDYL SULPHONE AMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | Astrazeneca AB (SE) | 2005-05-04 | — | — | EP | disclosed |
| WO-2004011443-A1 | PYRIMIDYL SULPHONE AMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | disclosed |