Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 0.59 |
| ▸ | KIT | P10721 | 4/20 | 0.59 |
| ▸ | KDR | P35968 | 4/20 | 0.59 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.58 |
| ▸ | LCK | P06239 | 2/20 | 0.58 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.58 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.56 |
| ▸ | SGK1 | O00141 | 1/20 | 0.53 |
| ▸ | RAF1 | P04049 | 1/20 | 0.52 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6171833 | 0.85 | MAPK14 (0.65) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL3524612 | 0.84 | MAPK14 (0.66) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL6171249 | 0.80 | MAPK14 (0.71) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL3525660 | 0.78 | MAPK13 (0.85) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL5123568 | 0.77 | MAPK14 (0.64) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL3524108 | 0.77 | MAPK13 (0.72) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL3527377 | 0.77 | MAPK14 (0.65) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL3521918 | 0.77 | MAPK13 (0.73) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL13349311 | 0.76 | MAPK14 (0.72) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL5098516 | 0.76 | MAPK14 (0.73) | MAPK14KITKDRMAPK9LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1531812-A1 | FUSED HETEROARYL DERIVATIVES FOR USE AS P38 KINASE INHIBITORS IN THE TREATMENT OF I.A. RHEUMATOID ARTHRISTIS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004010995-A1 | FUSED HETEROARYL DERIVATIVES FOR USE AS P38 KINASE INHIBITORS IN THE TREATMENT OF I.A. RHEUMATOID ARTHRISTIS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-02-05 | — | — | WO | disclosed |