Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 17/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 15/20 | 0.45 |
| ▸ | PPARA | Q07869 | 8/20 | 0.43 |
| ▸ | PPARG | P37231 | 7/20 | 0.43 |
| ▸ | PPARD | Q03181 | 7/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5576817 | 0.86 | NR1H3 (0.48) | NR1H3NR1H2PPARAPPARGPPARD | |
| SCHEMBL6165165 | 0.85 | NR1H3 (0.52) | NR1H3NR1H2PPARAPPARGPPARD | |
| SCHEMBL6405323 | 0.82 | NR1H2 (0.55) | NR1H3NR1H2PPARAPPARGPPARD | |
| SCHEMBL6167330 | 0.82 | NR1H3 (0.50) | NR1H3NR1H2PPARAPPARGPPARD | |
| SCHEMBL6405584 | 0.81 | NR1H2 (0.54) | NR1H3NR1H2PPARAPPARGPPARD | |
| SCHEMBL6406343 | 0.81 | NR1H2 (0.54) | NR1H3NR1H2PPARAPPARGPPARD | |
| SCHEMBL6168918 | 0.80 | NR1H3 (0.68) | NR1H3NR1H2PPARAPPARGPPARD | |
| SCHEMBL6405155 | 0.79 | NR1H2 (0.52) | NR1H3NR1H2PPARAPPARGPPARD | |
| SCHEMBL6404776 | 0.79 | NR1H2 (0.46) | NR1H3NR1H2PPARAPPARGPPARD | |
| SCHEMBL6406097 | 0.78 | NR1H2 (0.47) | NR1H3NR1H2PPARAPPARGPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458694-A4 | THERAPEUTIC COMPOUNDS FOR TREATING DYSLIPIDEMIC CONDITIONS | MERCK & CO INC (US) | 2005-12-14 | — | — | EP | disclosed |
| EP-1458694-A2 | THERAPEUTIC COMPOUNDS FOR TREATING DYSLIPIDEMIC CONDITIONS | Merck & Co., Inc. (US) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003053352-A2 | THERAPEUTIC COMPOUNDS FOR TREATING DYSLIPIDEMIC CONDITIONS | MERCK & CO., INC. (US) | 2003-07-03 | — | — | WO | disclosed |