Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS6 | Q8IU80 | 14/20 | 0.56 |
| ▸ | F2 | P00734 | 13/20 | 0.56 |
| ▸ | F10 | P00742 | 6/20 | 0.42 |
| ▸ | ST14 | Q9Y5Y6 | 3/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.39 |
| ▸ | F7 | P08709 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL6171857 | 0.92 | F2 (0.60) | TMPRSS6F2F10PRSS1PRSS2 | |
| Trifluoroacetic Acid SCHEMBL6171416 | 0.88 | TMPRSS6 (0.58) | TMPRSS6F2F10ST14PRSS1 | |
| Trifluoroacetic Acid SCHEMBL6169336 | 0.88 | TMPRSS6 (0.56) | TMPRSS6F2F10ST14 | |
| Trifluoroacetic Acid SCHEMBL6167095 | 0.82 | F10 (0.54) | TMPRSS6F2F10PRSS1PRSS2 | |
| Trifluoroacetic Acid SCHEMBL6173092 | 0.81 | F2 (0.54) | TMPRSS6F2F10PRSS1F7 | |
| Trifluoroacetic Acid SCHEMBL6171547 | 0.81 | F2 (0.53) | TMPRSS6F2F10PRSS1F7 | |
| Trifluoroacetic Acid SCHEMBL6161833 | 0.80 | F2 (0.48) | TMPRSS6F2F10PRSS1PRSS2 | |
| Trifluoroacetic Acid SCHEMBL6164683 | 0.80 | F9 (0.45) | TMPRSS6F2F10PRSS1PRSS2 | |
| Trifluoroacetic Acid SCHEMBL6166755 | 0.79 | F10 (0.54) | F2F10PRSS1PRSS2PRSS3 | |
| Trifluoroacetic Acid SCHEMBL6172396 | 0.79 | F2 (0.51) | TMPRSS6F2F10PRSS1F7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1254136-A4 | FACTOR Xa INHIBITORS WITH ARYL-AMIDINES AND DERIVATIVES, AND PRODRUGS THEREOF | LG CHEM INVESTMENT LTD (KR) | 2005-06-01 | — | — | EP | claimed |
| EP-1254136-A1 | FACTOR Xa INHIBITORS WITH ARYL-AMIDINES AND DERIVATIVES, AND PRODRUGS THEREOF | LG Chem Investment, Ltd. (KR) | 2002-11-06 | — | — | EP | claimed |
| WO-2001055146-A1 | FACTOR Xa INHIBITORS WITH ARYL-AMIDINES AND DERIVATIVES, AND PRODRUGS THEREOF | LG CHEM INVESTMENT LTD. (KR) | 2001-08-02 | — | — | WO | claimed |