Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 1/20 | 0.77 |
| ▸ | MME | P08473 | 1/20 | 0.76 |
| ▸ | LTA4H | P09960 | 1/20 | 0.76 |
| ▸ | ACE | P12821 | 2/20 | 0.72 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6169693 | 1.00 | ECE1 (0.77) | ECE1MMELTA4HACEHRH4 | |
| SCHEMBL6169688 | 1.00 | ECE1 (0.77) | ECE1MMELTA4HACEHRH4 | |
| SCHEMBL6169075 | 1.00 | ECE1 (0.77) | ECE1MMELTA4HACEHRH4 | |
| SCHEMBL6171492 | 0.95 | ECE1 (0.73) | ECE1MMELTA4HACE | |
| SCHEMBL6171226 | 0.95 | ECE1 (0.73) | ECE1MMELTA4HACE | |
| SCHEMBL6170852 | 0.95 | ECE1 (0.73) | ECE1MMELTA4HACE | |
| SCHEMBL11438476 | 0.93 | ECE1 (0.83) | ECE1ACE | |
| SCHEMBL4193332 | 0.93 | MME (0.77) | ECE1MMELTA4HACE | |
| SCHEMBL7321943 | 0.93 | ECE1 (0.70) | ECE1MMELTA4HACE | |
| SCHEMBL6169917 | 0.93 | MME (0.77) | ECE1MMELTA4HACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888341-B1 | NOVEL SULPHUR DERIVATIVES COMPRISING AN AMIDE BOND, METHOD FOR PREPARING SAME, USE THEREOF AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH DERIVATIVES | AVENTIS PHARMA SA (FR) | 2005-11-30 | — | — | EP | disclosed |
| US-6136842-A | INHIBITION OF ENDOTHELIN-CONVERTING ENZYME | HOECHST MARION ROUSSEL (FR) | 2000-10-24 | — | — | US | disclosed |
| US-6136995-A | Process for producing aminosilane compounds | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2000-10-24 | — | — | US | disclosed |
| EP-0888341-A1 | NOVEL SULPHUR DERIVATIVES COMPRISING AN AMIDE BOND, METHOD FOR PREPARING SAME, USE THEREOF AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH DERIVATIVES | HOECHST MARION ROUSSEL (FR) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997032874-A1 | NOVEL SULPHUR DERIVATIVES COMPRISING AN AMIDE BOND, METHOD FOR PREPARING SAME, USE THEREOF AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH DERIVATIVES | HOECHST MARION ROUSSEL (FR) | 1997-09-12 | — | — | WO | disclosed |
| EP-0566157-A1 | Neutral metalloendopeptidase inhibitors in the treatment of hypertension | SCHERING CORPORATION (US) | 1993-10-20 | — | — | EP | disclosed |
| US-5061710-A | Atrial natriuretic factors | SCHERING CORPORATION (US) | 1991-10-29 | — | — | US | disclosed |
| US-4929641-A | DIURETICS, ANGIOTENSIN CONVERTING ENZYMES | SCHERING CORPORATION (US) | 1990-05-29 | — | — | US | disclosed |
| US-4801609-A | Mercapto-acylamino acid antihypertensives | SCHERING CORPORATION (US) | 1989-01-31 | — | — | US | disclosed |
| EP-0254032-A2 | Neutral metalloendopeptidase inhibitors in the treatment of hypertension | SCHERING CORPORATION (US) | 1988-01-27 | — | — | EP | disclosed |