Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4709062 | 0.93 | PDE4B (0.52) | PDE4BSMN1; SMN2TP53CSF1RFGFR1 | |
| SCHEMBL4706054 | 0.92 | PDE4B (0.50) | PDE4BSMN1; SMN2TP53CSF1RFGFR1 | |
| SCHEMBL4708980 | 0.91 | PDE4B (0.48) | PDE4BSMN1; SMN2TP53CSF1RFGFR1 | |
| SCHEMBL4705820 | 0.90 | PDE4B (0.44) | PDE4BSMN1; SMN2TP53CSF1RFGFR1 | |
| SCHEMBL4707489 | 0.83 | PDE4B (0.48) | PDE4BSMN1; SMN2TP53CSF1RFGFR1 | |
| SCHEMBL4708625 | 0.81 | PDE4B (0.47) | PDE4BSMN1; SMN2TP53CSF1RFGFR1 | |
| SCHEMBL4708424 | 0.80 | PDE4B (0.46) | PDE4BSMN1; SMN2TP53CSF1RFGFR1 | |
| SCHEMBL4708024 | 0.80 | PDE4B (0.46) | PDE4BSMN1; SMN2TP53CSF1RFGFR1 | |
| SCHEMBL4708098 | 0.77 | PDE4B (0.54) | PDE4BSMN1; SMN2TP53CSF1RFGFR1 | |
| SCHEMBL3042557 | 0.76 | PDE4B (0.41) | PDE4BSMN1; SMN2CSF1RFGFR1FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1503992-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AS PDE4 INHIBITORS | Almirall Prodesfarma, S.A. (ES) | 2005-02-09 | — | — | EP | disclosed |
| WO-2003097613-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AS PDE4 INHIBITORS | ALMIRALL PRODESFARMA SA (ES) | 2003-11-27 | — | — | WO | disclosed |