Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 9/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 9/20 | 0.46 |
| ▸ | P2RY12 | Q9H244 | 7/20 | 0.46 |
| ▸ | PDE2A | O00408 | 3/20 | 0.46 |
| ▸ | DPP4 | P27487 | 5/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6168443 | 0.92 | PDE3B (0.46) | PDE3BPDE3AP2RY12PDE2APPARG | |
| SCHEMBL6167194 | 0.91 | DPP4 (0.47) | PDE3BPDE3AP2RY12PDE2ADPP4 | |
| SCHEMBL5414898 | 0.87 | PDE3B (0.45) | PDE3BPDE3AP2RY12PDE2ADYRK1A | |
| SCHEMBL5408087 | 0.86 | PDE3B (0.44) | PDE3BPDE3AP2RY12PDE2ADYRK1A | |
| SCHEMBL5412443 | 0.84 | PDE3B (0.43) | PDE3BPDE3AP2RY12PDE2ADPP4 | |
| SCHEMBL6168820 | 0.83 | PDE3B (0.45) | PDE3BPDE3AP2RY12PDE2ADPP4 | |
| SCHEMBL5421328 | 0.83 | PDE3B (0.50) | PDE3BPDE3AP2RY12PDE2ADPP4 | |
| SCHEMBL5412794 | 0.83 | PDE3B (0.50) | PDE3BPDE3AP2RY12PDE2ADPP4 | |
| SCHEMBL5420170 | 0.81 | PDE3B (0.45) | PDE3BPDE3AP2RY12PDE2ADPP4 | |
| SCHEMBL2330018 | 0.81 | PDE3B (0.48) | PDE3BPDE3AP2RY12PDE2AAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1404656-B9 | BENZIMIDAZOLE DERIVATIVES FOR TREATING MICROGLIA-ACTIVATION ASSOCIATED DISEASES SUCH AS INFLAMMATORY, ALLERGIC, INFECTIOUS OR AUTOIMMUNE DISEASES | SCHERING AG (DE) | 2005-10-19 | — | — | EP | claimed |
| EP-1404656-B1 | BENZIMIDAZOLE DERIVATIVES FOR TREATING MICROGLIA-ACTIVATION ASSOCIATED DISEASES SUCH AS INFLAMMATORY, ALLERGIC, INFECTIOUS OR AUTOIMMUNE DISEASES | SCHERING AG (DE) | 2005-05-18 | — | — | EP | claimed |