Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 18/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 18/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 18/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 18/20 | 0.51 |
| ▸ | PDE5A | O76074 | 1/20 | 0.45 |
| ▸ | PDE1A | P54750 | 1/20 | 0.45 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.45 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7380316 | 0.92 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL6173384 | 0.91 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL6174082 | 0.87 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6176170 | 0.87 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6171637 | 0.86 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6173149 | 0.86 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6171456 | 0.85 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6172169 | 0.85 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7514013 | 0.83 | PDE4B (0.61) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL8385725 | 0.83 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5892098-A | 3,3-(disubstituted)cyclohexan-1-one monomers and related compounds | SMITHKLINE BEECHAM CORPORATION (US) | 1999-04-06 | — | — | US | claimed |
| EP-0794774-B1 | 4,4-(DISUBSTITUTED)CYCLOHEXAN-1-OLS MONOMERS AND RELATED COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2005-10-12 | — | — | EP | disclosed |
| US-5977122-A | 4,4-(disubstituted)cyclohexan-1-ols monomers and related compounds | SMITHKLINE BEECHAM CORPORATION (US) | 1999-11-02 | — | — | US | disclosed |
| US-5891883-A | 4,4-(disubstituted)cyclohexan-1-ols monomers and related compounds | SMITHKLINE BEECHAM CORPORATION (US) | 1999-04-06 | — | — | US | disclosed |
| US-5892098-A | 3,3-(disubstituted)cyclohexan-1-one monomers and related compounds | SMITHKLINE BEECHAM CORPORATION (US) | 1999-04-06 | — | — | US | disclosed |
| EP-0828493-A4 | 4.4-(DISUBSTITUTED)CYCLOHEXAN-1-OLS-MONOMERS AND RELATED COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 1998-09-02 | — | — | EP | disclosed |
| EP-0794774-A4 | 4,4-(DISUBSTITUTED)CYCLOHEXAN-1-OLS MONOMERS AND RELATED COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 1998-04-29 | — | — | EP | disclosed |
| EP-0828493-A1 | 4.4-(DISUBSTITUTED)CYCLOHEXAN-1-OLS-MONOMERS AND RELATED COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-03-18 | — | — | EP | disclosed |
| EP-0794774-A1 | 4,4-(DISUBSTITUTED)CYCLOHEXAN-1-OLS MONOMERS AND RELATED COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-09-17 | — | — | EP | disclosed |
| WO-1996038150-A1 | 4.4-(DISUBSTITUTED)CYCLOHEXAN-1-OLS-MONOMERS AND RELATED COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-12-05 | — | — | WO | disclosed |
| WO-1996019988-A1 | 4,4-(DISUBSTITUTED)CYCLOHEXAN-1-OLS MONOMERS AND RELATED COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-07-04 | — | — | WO | disclosed |