Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 8/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | TAS2R8 | Q9NYW2 | 2/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2935050 | 0.92 | IGF1R (0.57) | IGF1RTAS2R8ROCK2 | |
| SCHEMBL2938896 | 0.85 | IGF1R (0.56) | IGF1RTAS2R8 | |
| SCHEMBL13039192 | 0.84 | IGF1R (0.58) | IGF1RAR | |
| SCHEMBL2942283 | 0.83 | IGF1R (0.45) | IGF1RMTNR1AMTNR1BROCK2 | |
| SCHEMBL2941511 | 0.83 | IGF1R (0.57) | IGF1RTAS2R8 | |
| SCHEMBL2933420 | 0.83 | IGF1R (0.57) | IGF1RTAS2R8 | |
| SCHEMBL2934568 | 0.82 | IGF1R (0.56) | IGF1R | |
| SCHEMBL2943395 | 0.82 | IGF1R (0.56) | IGF1RTRPV1 | |
| SCHEMBL2937204 | 0.82 | IGF1R (0.56) | IGF1R | |
| SCHEMBL2938070 | 0.81 | IGF1R (0.55) | IGF1RTRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |