Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 17/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6168049 | 0.93 | CCR1 (0.37) | CCR1TGFBR1ACVR1LMNA | |
| SCHEMBL3817009 | 0.85 | CETP (0.37) | LMNAMAPT | |
| SCHEMBL27642362 | 0.85 | CCR1 (0.46) | CCR1CYP2C19KCNH2 | |
| SCHEMBL4018787 | 0.82 | MEN1 (0.38) | LMNAMAPT | |
| SCHEMBL4016734 | 0.82 | CCR1 (0.62) | CCR1CYP2C19KCNH2 | |
| SCHEMBL4014768 | 0.81 | CCR1 (0.58) | CCR1CYP2C19KCNH2 | |
| SCHEMBL4019530 | 0.80 | CCR1 (0.47) | CCR1CYP2C19KCNH2 | |
| SCHEMBL27642359 | 0.80 | CCR1 (0.50) | CCR1CYP2C19KCNH2 | |
| SCHEMBL4018857 | 0.79 | CCR1 (0.47) | CCR1CYP2C19KCNH2 | |
| SCHEMBL4014775 | 0.79 | CCR1 (0.55) | CCR1CYP2C19KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1531822-A1 | 1-ARYL-4-SUBSTITUTED PIPERAZINE DERIVATIVES FOR USE AS CCR1 ANTAGONISTS FOR THE TREATMENT OF INFLAMMATION AND IMMUNE DISORDERS | Chemocentryx, Inc. (US) | 2005-05-25 | — | — | EP | disclosed |
| WO-2003105853-A1 | 1-ARYL-4-SUBSTITUTED PIPERAZINES DERIVATIVES FOR USE AS CCR1 ANTAGONISTS FOR THE TREATMENT OF INFLAMMATION AND IMMUNE DISORDERS | CHEMOCENTRYX, INC. (US) | 2003-12-24 | — | — | WO | disclosed |