Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 1/20 | 0.54 |
| ▸ | GLS | O94925 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 6/20 | 0.47 |
| ▸ | BCHE | P06276 | 4/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | FPR3 | P25089 | 1/20 | 0.43 |
| ▸ | FPR2 | P25090 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 2/20 | 0.42 |
| ▸ | CTSD | P07339 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8184393 | 0.92 | KDM4E (0.52) | ACKR3GLSMEN1ALDH1A1MAPT | |
| SCHEMBL7247256 | 0.89 | ACKR3 (0.55) | ACKR3GLSMEN1ALDH1A1MAPT | |
| SCHEMBL17207589 | 0.86 | ACKR3 (0.57) | ACKR3GLSMEN1ALDH1A1MAPT | |
| SCHEMBL4013905 | 0.86 | ACKR3 (0.60) | ACKR3GLSMEN1ALDH1A1MAPT | |
| SCHEMBL4013908 | 0.86 | ACKR3 (0.60) | ACKR3GLSMEN1ALDH1A1MAPT | |
| SCHEMBL3002627 | 0.86 | ACKR3 (0.57) | ACKR3GLSMEN1ALDH1A1MAPT | |
| SCHEMBL4014855 | 0.86 | ACKR3 (0.60) | ACKR3GLSMEN1ALDH1A1MAPT | |
| SCHEMBL3002618 | 0.86 | ACKR3 (0.57) | ACKR3GLSMEN1ALDH1A1MAPT | |
| SCHEMBL21509083 | 0.84 | MEN1 (0.62) | ACKR3GLSMEN1ALDH1A1MAPT | |
| SCHEMBL21509034 | 0.84 | MEN1 (0.62) | ACKR3GLSMEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1521582-A1 | 2,5-SUBSTITUTED PYRIMIDINE DERIVATIVES AS CCR-3 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-04-13 | — | — | EP | disclosed |
| WO-2004004731-A1 | 2, 5-SUBSTITUTED PYRIMIDINE DERIVATIVES AS CCR-3 RECEPTOR ANTAGONISTS IX | F. HOFFMANN-LA ROCHE AG (CH) | 2004-01-15 | — | — | WO | disclosed |