Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | CXCR3 | P49682 | 7/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | IGF1R | P08069 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | FPR1 | P21462 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6171681 | 0.87 | IGF1R (0.43) | KMT2AIGF1R | |
| SCHEMBL6173411 | 0.84 | KMT2A (0.37) | KMT2ACXCR3CYP3A4SMN1; SMN2USP2 | |
| SCHEMBL6174431 | 0.83 | KMT2A (0.39) | KMT2ACXCR3CYP3A4SMN1; SMN2USP2 | |
| SCHEMBL2935052 | 0.73 | IGF1R (0.42) | IGF1RTRPV1 | |
| SCHEMBL6174769 | 0.71 | IGF1R (0.39) | IGF1R | |
| SCHEMBL6175950 | 0.71 | CA1 (0.35) | KMT2ACYP3A4IGF1RTSHR | |
| SCHEMBL3728105 | 0.70 | IGF1R (0.47) | IGF1R | |
| SCHEMBL6175994 | 0.70 | CA1 (0.36) | KMT2ASMN1; SMN2IGF1R | |
| SCHEMBL2938005 | 0.69 | IGF1R (0.47) | IGF1R | |
| SCHEMBL2937467 | 0.68 | IGF1R (0.59) | IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |