Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.79 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.79 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.79 |
| ▸ | MAPK13 | O15264 | 9/20 | 0.75 |
| ▸ | MAPK12 | P53778 | 9/20 | 0.75 |
| ▸ | MAPK11 | Q15759 | 9/20 | 0.75 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.75 |
| ▸ | MAPK9 | P45984 | 6/20 | 0.75 |
| ▸ | RAF1 | P04049 | 7/20 | 0.70 |
| ▸ | BRAF | P15056 | 8/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6173735 | 0.91 | MAPK14 (0.81) | CSNK1A1CSNK1DRPS6KA3MAPK13MAPK12 | |
| SCHEMBL6171671 | 0.90 | MAPK14 (0.85) | CSNK1A1CSNK1DRPS6KA3MAPK13MAPK12 | |
| SCHEMBL4936886 | 0.89 | CSNK1A1 (1.00) | CSNK1A1CSNK1DRPS6KA3MAPK13MAPK12 | |
| SCHEMBL6174484 | 0.88 | CSNK1A1 (0.82) | CSNK1A1CSNK1DRPS6KA3MAPK13MAPK12 | |
| SCHEMBL6171459 | 0.88 | CSNK1A1 (0.73) | CSNK1A1CSNK1DRPS6KA3MAPK13MAPK12 | |
| SCHEMBL6171455 | 0.86 | MAPK14 (1.00) | CSNK1A1CSNK1DRPS6KA3MAPK13MAPK12 | |
| SCHEMBL6173136 | 0.84 | MAPK13 (1.00) | CSNK1A1CSNK1DRPS6KA3MAPK13MAPK12 | |
| SCHEMBL6172311 | 0.83 | MAPK14 (1.00) | CSNK1A1CSNK1DRPS6KA3MAPK13MAPK12 | |
| SCHEMBL6172619 | 0.83 | MAPK14 (1.00) | CSNK1A1CSNK1DRPS6KA3MAPK13MAPK12 | |
| SCHEMBL6172305 | 0.83 | MAPK14 (1.00) | CSNK1A1CSNK1DRPS6KA3MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906307-B1 | SUBSTITUTED IMIDAZOLES HAVING CYTOKINE INHIBITORY ACTIVITY | MERCK & CO INC (US) | 2005-04-27 | — | — | EP | disclosed |