SCHEMBL6172820

SCHEMBL6172820

CC(c1ccnc(Br)c1)C1(C(C)c2ccnc(Br)c2)NC(=O)N(c2ccc(SC(F)(F)F)cc2)C1=O

nearest known ligand 0.42

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
IGF1R P08069 19/20 0.42
AR P10275 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6175683 0.90 IGF1R (0.51) IGF1RAR
SCHEMBL6174494 0.90 IGF1R (0.42) IGF1RAR
SCHEMBL6174595 0.89 IGF1R (0.52) IGF1RAR
SCHEMBL6173683 0.89 IGF1R (0.52) IGF1RAR
SCHEMBL6175155 0.87 IGF1R (0.55) IGF1RAR
SCHEMBL17558389 0.87 IGF1R (0.53) IGF1RAR
SCHEMBL6176345 0.87 IGF1R (0.53) IGF1RAR
SCHEMBL6173628 0.86 IGF1R (0.40) IGF1RAR
SCHEMBL6173704 0.86 IGF1R (0.45) IGF1RAR
SCHEMBL6174941 0.86 IGF1R (0.45) IGF1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1599464-A2 NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS Aventis Pharma S.A. (FR) 2005-11-30 EP disclosed
WO-2004070050-A2 CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS AVENTIS PHARMA S.A. (FR) 2004-08-19 WO disclosed