Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.42 |
| ▸ | CNR1 | P21554 | 2/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 2/20 | 0.32 |
| ▸ | TRPV3 | Q8NET8 | 3/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | HTR1D | P28221 | 1/20 | 0.31 |
| ▸ | HTR1B | P28222 | 1/20 | 0.31 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.30 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.30 |
| ▸ | BRAF | P15056 | 1/20 | 0.30 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6171792 | 0.89 | IGF1R (0.44) | IGF1RCNR1ARKMT2ACYP2C9 | |
| SCHEMBL6173145 | 0.88 | IGF1R (0.43) | IGF1RCNR1ARKMT2ACYP2C9 | |
| SCHEMBL6174619 | 0.88 | IGF1R (0.43) | IGF1RCNR1ARKMT2ACYP2C9 | |
| SCHEMBL6174593 | 0.86 | IGF1R (0.42) | IGF1RARKMT2ACYP2C9THRB | |
| SCHEMBL6174623 | 0.86 | IGF1R (0.42) | IGF1RCNR1ARKMT2ACYP2C9 | |
| SCHEMBL6172509 | 0.85 | TRPV1 (0.36) | ARKMT2ACYP2C9RIPK3BRAF | |
| SCHEMBL6172678 | 0.85 | IGF1R (0.41) | IGF1R | |
| SCHEMBL6176113 | 0.83 | IGF1R (0.42) | IGF1RARKMT2ACYP2C9TP53 | |
| SCHEMBL6172616 | 0.81 | IGF1R (0.41) | IGF1RARKMT2ATP53TRPV3 | |
| SCHEMBL6172256 | 0.81 | IGF1R (0.42) | IGF1RARKMT2ATP53TRPV3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |