Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 14/20 | 0.57 |
| ▸ | ESR2 | Q92731 | 14/20 | 0.57 |
| ▸ | ENPP3 | O14638 | 3/20 | 0.51 |
| ▸ | ENPP1 | P22413 | 3/20 | 0.51 |
| ▸ | MOK | Q9UQ07 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7450865 | 0.93 | ESR1 (0.56) | ESR1ESR2ENPP3ENPP1 | |
| SCHEMBL6173615 | 0.89 | ESR1 (0.68) | ESR1ESR2 | |
| SCHEMBL6171805 | 0.88 | ESR1 (0.60) | ESR1ESR2ENPP3ENPP1 | |
| SCHEMBL6598683 | 0.86 | ESR1 (0.70) | ESR1ESR2ENPP3ENPP1 | |
| SCHEMBL6170231 | 0.85 | ESR1 (0.56) | ESR1ESR2ENPP3ENPP1 | |
| SCHEMBL7446013 | 0.82 | ESR1 (0.71) | ESR1ESR2ENPP3ENPP1 | |
| SCHEMBL7768048 | 0.82 | F2 (0.58) | ESR1ESR2 | |
| SCHEMBL6597618 | 0.80 | ESR1 (0.49) | ESR1ESR2ENPP3ENPP1 | |
| SCHEMBL7452932 | 0.80 | ESR1 (0.76) | ESR1ESR2ENPP3ENPP1 | |
| SCHEMBL7774305 | 0.78 | ESR1 (0.79) | ESR1ESR2ENPP3ENPP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1027051-B1 | ANTITHROMBOTIC AGENTS | LILLY CO ELI (US) | 2005-01-05 | — | — | EP | disclosed |
| EP-0973517-A4 | ANTITHROMBOTIC AGENTS | LILLY CO ELI (US) | 2002-07-24 | — | — | EP | disclosed |
| US-6391901-B1 | Thrombin inhibitors | ELI LILLY AND COMPANY | 2002-05-21 | — | — | US | disclosed |
| US-6288105-B1 | COMPOUNDS SUCH AS (S)-2-(4-((2-AMINO-3-HYDROXY-1-OXOPROPYL)AMINO)PHENYL)-6-HYDRO XY-3-(3-METHOXY-4-(1-PYRROLIDINYLMETHYL)BENZYL)BENZO(B)THIOPHE NE | ELI LILLY AND COMPANY | 2001-09-11 | — | — | US | disclosed |
| EP-0973517-A1 | ANTITHROMBOTIC AGENTS | ELI LILLY AND COMPANY (US) | 2000-01-26 | — | — | EP | disclosed |
| WO-1998048794-A1 | ANTITHROMBOTIC AGENTS | ELI LILLY AND COMPANY (US) | 1998-11-05 | — | — | WO | disclosed |