Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 15/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5654369 | 1.00 | MIF (0.40) | MIFCYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL5655145 | 0.88 | PDE3B (0.42) | MIFPDE3BPDE3A | |
| SCHEMBL5655143 | 0.88 | PDE3B (0.42) | MIFPDE3BPDE3A | |
| SCHEMBL5654140 | 0.87 | MIF (0.39) | MIFPDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL5654239 | 0.87 | MIF (0.39) | MIFPDE3BPDE3A | |
| SCHEMBL5654236 | 0.87 | MIF (0.39) | MIFPDE3BPDE3A | |
| SCHEMBL5654137 | 0.87 | MIF (0.39) | MIFPDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL5653159 | 0.85 | MIF (0.38) | MIFPDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL5653151 | 0.85 | MIF (0.38) | MIFPDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL5654604 | 0.85 | MIF (0.45) | MIFMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242416-B1 | SUBSTITUTED ISOXAZOLINES AND THEIR USE AS ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2005-04-13 | — | — | EP | disclosed |