Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.34 |
| ▸ | NAMPT | P43490 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6175557 | 0.91 | GAA (0.36) | IGF1RNAMPTCYP2C9ALDH1A1CYP3A4 | |
| SCHEMBL6172175 | 0.88 | IGF1R (0.37) | IGF1RCYP2C9ALDH1A1CYP3A4GAA | |
| SCHEMBL6174680 | 0.85 | IGF1R (0.37) | IGF1RNAMPTCYP2C9ALDH1A1CYP3A4 | |
| SCHEMBL3728080 | 0.84 | IGF1R (0.51) | IGF1RNAMPT | |
| SCHEMBL6175985 | 0.84 | IGF1R (0.41) | IGF1RNAMPTCYP2C9ALDH1A1CYP3A4 | |
| SCHEMBL6174414 | 0.83 | IGF1R (0.38) | IGF1RNAMPTCYP2C9THRBMAPT | |
| SCHEMBL2939804 | 0.80 | IGF1R (0.33) | IGF1RNAMPTRXFP1 | |
| SCHEMBL6171908 | 0.80 | NAMPT (0.49) | IGF1RNAMPTCYP2C9 | |
| SCHEMBL2941322 | 0.80 | IGF1R (0.51) | IGF1RNAMPTRXFP1 | |
| SCHEMBL6176685 | 0.79 | IGF1R (0.39) | IGF1RNAMPTCYP2C9ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |