Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 6/20 | 0.55 |
| ▸ | CDK2 | P24941 | 6/20 | 0.55 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.55 |
| ▸ | STAT3 | P40763 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 1/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | CCND1 | P24385 | 1/20 | 0.44 |
| ▸ | CDK7 | P50613 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | CCNH | P51946 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6176276 | 0.86 | CCNE1 (0.50) | CCNE1CDK2CDK5STAT3MEN1 | |
| SCHEMBL5835210 | 0.85 | CCNE1 (0.50) | CCNE1CDK2CDK5STAT3MEN1 | |
| SCHEMBL5836294 | 0.83 | MEN1 (0.59) | CCNE1CDK2CDK5STAT3MEN1 | |
| SCHEMBL5835451 | 0.83 | CCNE1 (0.57) | CCNE1CDK2CDK5STAT3MEN1 | |
| SCHEMBL6185862 | 0.83 | CCNE1 (0.57) | CCNE1CDK2CDK5STAT3MEN1 | |
| SCHEMBL5835824 | 0.83 | STAT3 (0.59) | CCNE1CDK2CDK5STAT3MEN1 | |
| SCHEMBL5835140 | 0.81 | MAPT (0.59) | CCNE1CDK2CDK5MEN1KMT2A | |
| SCHEMBL5835657 | 0.81 | CCNE1 (0.55) | CCNE1CDK2CDK5STAT3MEN1 | |
| SCHEMBL5835693 | 0.79 | CCNE1 (0.55) | CCNE1CDK2CDK5STAT3MEN1 | |
| SCHEMBL6172910 | 0.78 | CDK2 (0.43) | CCNE1CDK2CDK5STAT3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1124810-B9 | 2-AMINO-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-12-28 | — | — | EP | claimed |
| EP-1124810-B1 | 2-AMINO-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-05-04 | — | — | EP | claimed |