Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 15/20 | 0.41 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6173046 | 0.87 | CYP3A4 (0.37) | AR | |
| SCHEMBL6173157 | 0.86 | IGF1R (0.45) | IGF1RAR | |
| SCHEMBL6173965 | 0.84 | IGF1R (0.43) | IGF1RNTRK1ARNPC1RAB9A | |
| SCHEMBL6172562 | 0.82 | IGF1R (0.47) | IGF1RAR | |
| SCHEMBL2938901 | 0.82 | IGF1R (0.60) | IGF1R | |
| SCHEMBL6172954 | 0.82 | IGF1R (0.38) | IGF1RTACR1NTRK1 | |
| SCHEMBL6173545 | 0.81 | IGF1R (0.46) | IGF1RNTRK1AR | |
| SCHEMBL6175503 | 0.81 | IGF1R (0.48) | IGF1RNTRK1AR | |
| SCHEMBL6174069 | 0.81 | IGF1R (0.48) | IGF1RAR | |
| SCHEMBL6174374 | 0.81 | IGF1R (0.48) | IGF1RNTRK1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |