Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 7/20 | 0.53 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 1/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | CCND1 | P24385 | 1/20 | 0.44 |
| ▸ | CDK7 | P50613 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | CCNH | P51946 | 1/20 | 0.44 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.44 |
| ▸ | FDPS | P14324 | 1/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6174076 | 0.75 | CDK2 (0.50) | CDK2CCNE1CDK5SMN1; SMN2ALDH1A1 | |
| SCHEMBL6174654 | 0.74 | CDK2 (0.51) | CDK2CCNE1CDK5SMN1; SMN2ALDH1A1 | |
| SCHEMBL681610 | 0.71 | CDK2 (0.73) | CDK2CCNE1CDK5SMN1; SMN2ALDH1A1 | |
| SCHEMBL5835781 | 0.70 | NPC1 (0.66) | CDK2CCNE1CDK5SMN1; SMN2ALDH1A1 | |
| SCHEMBL5836061 | 0.70 | CDK2 (0.62) | CDK2CCNE1CDK5SMN1; SMN2ALDH1A1 | |
| SCHEMBL5836102 | 0.70 | CDK2 (1.00) | CDK2CCNE1CDK5SMN1; SMN2ALDH1A1 | |
| SCHEMBL24624620 | 0.70 | CDK2 (0.71) | CDK2CCNE1CDK5SMN1; SMN2ALDH1A1 | |
| SCHEMBL27574298 | 0.70 | CDK2 (0.71) | CDK2CCNE1CDK5SMN1; SMN2ALDH1A1 | |
| SCHEMBL2463824 | 0.70 | CDK2 (1.00) | CDK2CCNE1CDK5SMN1; SMN2ALDH1A1 | |
| SCHEMBL5836867 | 0.69 | CDK2 (0.61) | CDK2CCNE1CDK5SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1124810-B9 | 2-AMINO-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-12-28 | — | — | EP | claimed |
| EP-1124810-B1 | 2-AMINO-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-05-04 | — | — | EP | claimed |