Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 15/20 | 0.78 |
| ▸ | EGFR | P00533 | 11/20 | 0.78 |
| ▸ | FECH | P22830 | 1/20 | 0.78 |
| ▸ | CDK8 | P49336 | 1/20 | 0.78 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.78 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.78 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.78 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.49 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.49 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.46 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6174252 | 1.00 | ERBB2 (0.78) | ERBB2EGFRFECHCDK8MAP2K5 | |
| SCHEMBL4617369 | 0.93 | EGFR (0.67) | ERBB2EGFRFECHCDK8MAP2K5 | |
| SCHEMBL4617364 | 0.93 | EGFR (0.67) | ERBB2EGFRFECHCDK8MAP2K5 | |
| SCHEMBL4797940 | 0.90 | ERBB2 (0.79) | ERBB2EGFRFECHCDK8MAP2K5 | |
| SCHEMBL4797951 | 0.90 | ERBB2 (0.79) | ERBB2EGFRFECHCDK8MAP2K5 | |
| SCHEMBL2980655 | 0.90 | ERBB2 (0.63) | ERBB2EGFRFECHCDK8MAP2K5 | |
| SCHEMBL2980652 | 0.90 | ERBB2 (0.63) | ERBB2EGFRFECHCDK8MAP2K5 | |
| SCHEMBL6175901 | 0.90 | ERBB2 (0.83) | ERBB2EGFRFECHCDK8MAP2K5 | |
| SCHEMBL6170353 | 0.90 | ERBB2 (0.83) | ERBB2EGFRFECHCDK8MAP2K5 | |
| SCHEMBL5982303 | 0.90 | ERBB2 (0.83) | ERBB2EGFRFECHCDK8MAP2K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1292591-B1 | SUBSTITUTED BICYCLIC DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | PFIZER PROD INC (US) | 2005-02-02 | — | — | EP | disclosed |