Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 13/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.47 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6176489 | 0.92 | ERBB2 (0.54) | EGFRERBB2HDAC3HDAC4HDAC1 | |
| SCHEMBL6175531 | 0.87 | ERBB2 (0.51) | EGFRERBB2HDAC3HDAC4HDAC1 | |
| SCHEMBL6172180 | 0.86 | ERBB2 (0.61) | EGFRERBB2HDAC1HDAC6ERBB4 | |
| SCHEMBL6173784 | 0.86 | ERBB2 (0.49) | EGFRERBB2HDAC3HDAC4HDAC1 | |
| SCHEMBL6177169 | 0.85 | ERBB2 (0.53) | EGFRERBB2HDAC3HDAC4HDAC1 | |
| SCHEMBL6189113 | 0.85 | ERBB2 (0.51) | EGFRERBB2HDAC3HDAC4HDAC1 | |
| SCHEMBL6171826 | 0.84 | ERBB2 (0.62) | EGFRERBB2HDAC3HDAC4HDAC1 | |
| SCHEMBL6173857 | 0.84 | ERBB2 (0.52) | EGFRERBB2HDAC3HDAC4HDAC1 | |
| SCHEMBL6176765 | 0.84 | ERBB2 (0.55) | EGFRERBB2HDAC3HDAC4HDAC1 | |
| SCHEMBL6174290 | 0.84 | ERBB2 (0.53) | EGFRERBB2HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1292591-B1 | SUBSTITUTED BICYCLIC DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | PFIZER PROD INC (US) | 2005-02-02 | — | — | EP | disclosed |