Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 11/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6187298 | 1.00 | SLC6A2 (0.34) | SLC6A2SLC6A4SLC6A3CYP2D6HTR2C | |
| SCHEMBL6170254 | 1.00 | SLC6A2 (0.34) | SLC6A2SLC6A4SLC6A3CYP2D6HTR2C | |
| SCHEMBL6171159 | 0.81 | SLC6A2 (0.40) | SLC6A2SLC6A4SLC6A3CYP2D6HTR2C | |
| SCHEMBL6171785 | 0.81 | SLC6A2 (0.40) | SLC6A2SLC6A4SLC6A3CYP2D6HTR2C | |
| SCHEMBL4028181 | 0.80 | SLC6A2 (0.39) | SLC6A2SLC6A4SLC6A3CYP2D6HTR2C | |
| SCHEMBL4024571 | 0.80 | SLC6A2 (0.39) | SLC6A2SLC6A4SLC6A3CYP2D6HTR2C | |
| SCHEMBL4019257 | 0.80 | SLC6A2 (0.39) | SLC6A2SLC6A4SLC6A3CYP2D6HTR2C | |
| SCHEMBL4025554 | 0.80 | SLC6A2 (0.39) | SLC6A2SLC6A4SLC6A3CYP2D6HTR2C | |
| SCHEMBL4681356 | 0.78 | SLC6A4 (0.36) | SLC6A2SLC6A4SLC6A3HTR2C | |
| SCHEMBL13720388 | 0.78 | SLC6A4 (0.36) | SLC6A2SLC6A4SLC6A3HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569934-A2 | CYCLOPROPYL COMPOUNDS AS CCR5 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-09-07 | — | — | EP | disclosed |
| WO-2004055010-A2 | CYCLOPROPYL COMPOUNDS AS CCR5 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-07-01 | — | — | WO | disclosed |