Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | DGAT2 | Q96PD7 | 3/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 3/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | VNN1 | O95497 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | P2RY1 | P47900 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6175120 | 0.90 | IGF1R (0.45) | CYP3A4GAACYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL6173204 | 0.84 | CACNA1B (0.37) | CYP3A4GAACYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL6177675 | 0.81 | SCN10A (0.41) | CYP3A4GAACYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL2943931 | 0.75 | IGF1R (0.46) | CYP3A4SLC22A12IGF1R | |
| SCHEMBL6174506 | 0.74 | CYP3A4 (0.43) | CYP3A4GAACYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL2938143 | 0.70 | IGF1R (0.47) | IGF1R | |
| SCHEMBL2933138 | 0.69 | GCGR (0.43) | CYP3A4GAACYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL2938618 | 0.69 | MCHR1 (0.49) | CYP3A4SLC22A12 | |
| SCHEMBL2940974 | 0.69 | IGF1R (0.48) | CYP3A4GAACYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL2939757 | 0.69 | IGF1R (0.46) | CYP3A4IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |