Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.73 |
| ▸ | ERBB2 | P04626 | 11/20 | 0.73 |
| ▸ | FECH | P22830 | 1/20 | 0.73 |
| ▸ | CDK8 | P49336 | 1/20 | 0.73 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.73 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.73 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.73 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4798798 | 1.00 | EGFR (0.73) | EGFRERBB2FECHCDK8MAP2K5 | |
| SCHEMBL4798789 | 1.00 | EGFR (0.73) | EGFRERBB2FECHCDK8MAP2K5 | |
| SCHEMBL6174127 | 0.93 | EGFR (0.74) | EGFRERBB2FECHCDK8MAP2K5 | |
| SCHEMBL6175088 | 0.93 | EGFR (0.74) | EGFRERBB2FECHCDK8MAP2K5 | |
| SCHEMBL6175084 | 0.93 | EGFR (0.74) | EGFRERBB2FECHCDK8MAP2K5 | |
| SCHEMBL6174132 | 0.93 | EGFR (0.74) | EGFRERBB2FECHCDK8MAP2K5 | |
| SCHEMBL6174350 | 0.93 | ERBB2 (0.85) | EGFRERBB2FECHCDK8MAP2K5 | |
| SCHEMBL6174343 | 0.93 | ERBB2 (0.85) | EGFRERBB2FECHCDK8MAP2K5 | |
| SCHEMBL4618014 | 0.92 | EGFR (0.86) | EGFRERBB2FECHCDK8MAP2K5 | |
| SCHEMBL4618016 | 0.92 | EGFR (0.86) | EGFRERBB2FECHCDK8MAP2K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1292591-B1 | SUBSTITUTED BICYCLIC DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | PFIZER PROD INC (US) | 2005-02-02 | — | — | EP | disclosed |