Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 2/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.32 |
| ▸ | LIPE | Q05469 | 3/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | CTSD | P07339 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6174465 | 0.90 | MAPK7 (0.39) | TRPV1POLBL3MBTL1ARAAK1 | |
| SCHEMBL6177961 | 0.90 | MAPK7 (0.39) | TRPV1POLBL3MBTL1ARCYP3A4 | |
| SCHEMBL6176261 | 0.89 | DDR1 (0.38) | TRPV1POLBL3MBTL1ARAAK1 | |
| SCHEMBL6172700 | 0.89 | TRPV1 (0.46) | TRPV1POLBL3MBTL1ARMEN1 | |
| SCHEMBL6172509 | 0.88 | TRPV1 (0.36) | TRPV1POLBL3MBTL1ARMEN1 | |
| SCHEMBL6175539 | 0.88 | TRPV1 (0.34) | TRPV1POLBL3MBTL1ARAAK1 | |
| SCHEMBL6175751 | 0.87 | AR (0.41) | TRPV1POLBL3MBTL1ARKMT2A | |
| SCHEMBL6173145 | 0.85 | IGF1R (0.43) | ARMEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL3729343 | 0.85 | MAPK7 (0.42) | POLBL3MBTL1ARCYP3A4GAA | |
| SCHEMBL6175201 | 0.85 | MAPK7 (0.39) | TRPV1POLBL3MBTL1ARKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |