Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 18/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6173427 | 1.00 | IGF1R (0.45) | IGF1RARNTRK1 | |
| Trifluoroacetic Acid SCHEMBL17558379 | 0.95 | IGF1R (0.42) | IGF1RARNTRK1 | |
| SCHEMBL6174389 | 0.89 | IGF1R (0.42) | IGF1R | |
| SCHEMBL6173605 | 0.88 | IGF1R (0.45) | IGF1RAR | |
| SCHEMBL6176318 | 0.87 | IGF1R (0.42) | IGF1RAR | |
| SCHEMBL6174285 | 0.87 | IGF1R (0.46) | IGF1RAR | |
| SCHEMBL6174899 | 0.86 | IGF1R (0.45) | IGF1R | |
| SCHEMBL6172290 | 0.86 | IGF1R (0.45) | IGF1R | |
| SCHEMBL6175290 | 0.86 | IGF1R (0.43) | IGF1RNTRK1 | |
| SCHEMBL6174017 | 0.86 | IGF1R (0.43) | IGF1RAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3188729-A1 | CYCLIC UREA COMPOUNDS AS TROPOMYOSIN-RELATED KINASE (TRK) INHIBITORS | Genzyme Corporation (US) | 2017-07-12 | — | — | EP | disclosed |
| WO-2016036796-A1 | CYCLIC UREA COMPOUNDS AS TROPOMYOSIN-RELATED KINASE (TRK) INHIBITORS | GENZYME CORPORATION (US) | 2016-03-10 | — | — | WO | disclosed |
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |