Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 1/20 | 0.50 |
| ▸ | BRAF | P15056 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.47 |
| ▸ | WNT3A | P56704 | 1/20 | 0.46 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.44 |
| ▸ | SLC2A4 | P14672 | 1/20 | 0.44 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | GCGR | P47871 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6176784 | 0.93 | MAPK14 (0.53) | SRCBRAFKDRMAPK14MAPK13 | |
| SCHEMBL6179013 | 0.91 | MAPK14 (0.53) | SRCBRAFKDRMAPK14MAPK13 | |
| SCHEMBL4336481 | 0.88 | MAPK14 (0.57) | SRCBRAFKDRMAPK14MAPK13 | |
| SCHEMBL6176619 | 0.84 | MAPK14 (0.46) | SRCBRAFKDRMAPK14MAPK13 | |
| SCHEMBL6175734 | 0.83 | MAPK14 (0.48) | SRCBRAFKDRMAPK14PTGDR2 | |
| SCHEMBL6180262 | 0.81 | MAPK14 (0.56) | SRCBRAFKDRMAPK14WNT3A | |
| SCHEMBL6177991 | 0.80 | MAPK14 (0.48) | SRCBRAFKDRMAPK14PTGDR2 | |
| SCHEMBL6178593 | 0.80 | MAPK14 (0.48) | SRCBRAFKDRMAPK14MAPK13 | |
| SCHEMBL6028828 | 0.80 | SRC (0.49) | SRCBRAFKDRMAPK14SLC2A1 | |
| SCHEMBL6177608 | 0.80 | MAPK14 (0.47) | SRCBRAFKDRMAPK14MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1326848-C | Aminopyrazole derivatives | TEIKOKU HORMONE MFG CO LTD (JP) | 2007-07-18 | — | — | CN | disclosed |
| EP-1142890-B1 | AMINOPYRAZOLE DERIVATIVES | TEIKOKU HORMONE MFG CO LTD (JP) | 2005-08-03 | — | — | EP | disclosed |
| US-6511997-B1 | For treatment of a disease associated with tumor necrosis factor alpha, interleukin 1, interleukin 6 or cyclooxygenase II; such as irritable bowel disease | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2003-01-28 | — | — | US | disclosed |
| CN-1331688-A | Aminopyridine Derivatives | TEIKOKU HORMONE MFG CO LTD (JP) | 2002-01-16 | — | — | CN | disclosed |
| EP-1142890-A1 | AMINOPYRAZOLE DERIVATIVES | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2001-10-10 | — | — | EP | disclosed |