Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRAS | P01112 | 14/20 | 0.53 |
| ▸ | ESR1 | P03372 | 13/20 | 0.53 |
| ▸ | ESR2 | Q92731 | 13/20 | 0.53 |
| ▸ | TOP1 | P11387 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 2/20 | 0.36 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7533826 | 0.89 | HRAS (0.48) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL7533731 | 0.89 | HRAS (0.48) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL7838380 | 0.87 | TOP1 (0.42) | HRASESR1ESR2TOP1KDM4E | |
| Hydrochloric Acid SCHEMBL10690247 | 0.87 | KDM4E (0.69) | HRASESR1ESR2TOP1KDM4E | |
| Hydrochloric Acid SCHEMBL10693519 | 0.87 | KDM4E (0.69) | HRASESR1ESR2TOP1KDM4E | |
| Hydrochloric Acid SCHEMBL6178124 | 0.84 | TOP1 (0.55) | HRASESR1ESR2TOP1KDM4E | |
| Hydrochloric Acid SCHEMBL6178110 | 0.83 | KDM4E (0.56) | HRASESR1ESR2TOP1KDM4E | |
| Hydrochloric Acid SCHEMBL6176662 | 0.83 | KDM4E (0.58) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL26643148 | 0.83 | TOP1 (0.47) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL26643141 | 0.83 | HRAS (0.59) | HRASESR1ESR2TOP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1064281-B1 | BENZOHETEROCYCLIC DISTAMYCIN DERIVATIVES, PROCESS FOR PREPARING THEM, AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-05-25 | — | — | EP | disclosed |
| US-6458768-B1 | ANTITUMOR AGENTS THAT CAN BE FORMULATED WITH A COMPOUND ALTERNATIVELY, CAN BE ADMINISTERED IN A MIXTURE OF DRUGS | PHARMACIA & UPJOHN, S.P.A. (IT) | 2002-10-01 | — | — | US | disclosed |
| EP-0912509-B1 | DISTAMYCIN DERIVATIVES, PROCESS FOR PREPARING THEM, AND THEIR USE AS ANTITUMOR AND ANTIVIRAL AGENTS | PHARMACIA & UPJOHN SPA (IT) | 2001-07-11 | — | — | EP | disclosed |
| US-6177408-B1 | COMPOUNDS SUCH AS 3-(1-METHYL-4(1-METHYL-4(1-METHYL-4(4-N,N-BIS(2 -CHLOROETHYL)AMINOCINNAMOYLAMIDO)PYRROLE-2-CARBOXAMIDO)PYRROLE-2 -CARBOXAMIDO)PYRROLE-2-CARBOXAMIDO)PROPIONAMIDINE | PHARMACIA & UPJOHN S.P.A. (IT) | 2001-01-23 | — | — | US | disclosed |
| US-6165980-A | Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents | PHARMACIA & UPJOHN S.P.A. (IT) | 2000-12-26 | — | — | US | disclosed |