Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 10/20 | 0.54 |
| ▸ | SRC | P12931 | 4/20 | 0.52 |
| ▸ | BRAF | P15056 | 4/20 | 0.52 |
| ▸ | KDR | P35968 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.42 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.42 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.42 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4338017 | 0.87 | MAPK14 (0.55) | MAPK14KDM4EEGFR | |
| SCHEMBL6176484 | 0.86 | MAPK14 (0.53) | MAPK14SRCBRAFKDRRIPK2 | |
| SCHEMBL4338910 | 0.85 | MAPK14 (0.52) | MAPK14SRCBRAFKDRRIPK2 | |
| SCHEMBL6177187 | 0.79 | SRC (0.50) | MAPK14SRCBRAFKDRRIPK2 | |
| SCHEMBL6176150 | 0.79 | BRAF (0.55) | MAPK14SRCBRAFKDRKDM4E | |
| SCHEMBL6178426 | 0.78 | MAPK14 (0.56) | MAPK14SRCBRAFKDRKDM4E | |
| SCHEMBL4329813 | 0.78 | MAPK14 (0.56) | MAPK14SRCBRAFKDRKDM4E | |
| SCHEMBL6176783 | 0.78 | MAPK14 (0.50) | MAPK14SRCBRAFKDRKDM4E | |
| SCHEMBL4329196 | 0.78 | MAPK14 (0.55) | MAPK14SRCBRAFKDRKDM4E | |
| SCHEMBL4336955 | 0.78 | MAPK14 (0.52) | MAPK14SRCBRAFKDRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1142890-B1 | AMINOPYRAZOLE DERIVATIVES | TEIKOKU HORMONE MFG CO LTD (JP) | 2005-08-03 | — | — | EP | disclosed |
| US-6511997-B1 | For treatment of a disease associated with tumor necrosis factor alpha, interleukin 1, interleukin 6 or cyclooxygenase II; such as irritable bowel disease | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2003-01-28 | — | — | US | disclosed |
| EP-1142890-A1 | AMINOPYRAZOLE DERIVATIVES | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2001-10-10 | — | — | EP | disclosed |