Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.65 |
| ▸ | ATM | Q13315 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | FAAH | O00519 | 1/20 | 0.51 |
| ▸ | APP | P05067 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1858096 | 0.98 | HCAR2 (0.66) | HCAR2ATMMAPTFAAHAPP | |
| SCHEMBL15365962 | 0.98 | HCAR2 (0.66) | HCAR2ATMMAPTFAAHAPP | |
| SCHEMBL8032532 | 0.98 | HCAR2 (0.66) | HCAR2ATMMAPTFAAHAPP | |
| SCHEMBL15366125 | 0.98 | HCAR2 (0.66) | HCAR2ATMMAPTFAAHAPP | |
| SCHEMBL10857755 | 0.98 | HCAR2 (0.66) | HCAR2ATMMAPTFAAHAPP | |
| SCHEMBL3016477 | 0.98 | HCAR2 (0.66) | HCAR2ATMMAPTFAAHAPP | |
| SCHEMBL15365968 | 0.98 | HCAR2 (0.66) | HCAR2ATMMAPTFAAHAPP | |
| SCHEMBL1852690 | 0.98 | HCAR2 (0.66) | HCAR2ATMMAPTFAAHAPP | |
| SCHEMBL1572962 | 0.98 | HCAR2 (0.66) | HCAR2ATMMAPTFAAHAPP | |
| SCHEMBL10852072 | 0.98 | HCAR2 (0.66) | HCAR2ATMMAPTFAAHAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1528059-A2 | Substituted isoxazoles for the treatment of inflammation | G.D. Searle LLC (US) | 2005-05-04 | — | — | EP | disclosed |
| EP-0809636-B1 | SUBSTITUTED ISOXAZOLES FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2002-09-04 | — | — | EP | disclosed |
| EP-1223167-A2 | Substituted isoxazoles for the treatment of inflammation | G.D. Searle & Co. (US) | 2002-07-17 | — | — | EP | disclosed |
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5859257-A | ANTIINFLAMMATORY, ANTIARTHRITIC AGENTS | G. D. SEARLE & CO. (US) | 1999-01-12 | — | — | US | disclosed |
| EP-0809636-A1 | SUBSTITUTED ISOXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-12-03 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996025405-A1 | SUBSTITUTED ISOXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-08-22 | — | — | WO | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |