Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 9/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.35 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6175915 | 0.88 | IGF1R (0.42) | IGF1RMAPK10MAPK8MAPK14PDE2A | |
| SCHEMBL6173796 | 0.88 | IGF1R (0.52) | IGF1RPDE2A | |
| SCHEMBL6177806 | 0.83 | IGF1R (0.43) | IGF1RPDE2A | |
| SCHEMBL6174748 | 0.83 | IGF1R (0.43) | IGF1RPDE2A | |
| SCHEMBL6174986 | 0.82 | IGF1R (0.42) | IGF1RPDE2A | |
| SCHEMBL6174049 | 0.82 | IGF1R (0.46) | IGF1R | |
| SCHEMBL6174396 | 0.81 | IGF1R (0.58) | IGF1RKDM4EALDH1A1L3MBTL1HRH4 | |
| SCHEMBL6172754 | 0.80 | IGF1R (0.41) | IGF1RKDM4EPDE2A | |
| SCHEMBL6174760 | 0.80 | IGF1R (0.41) | IGF1RMAPK9MAPK10PDE2A | |
| SCHEMBL6173932 | 0.79 | IGF1R (0.40) | IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |