Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.46 |
| ▸ | POLQ | O75417 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.40 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6176304 | 0.91 | MAPK14 (0.46) | KDM4EMAPK14MAPTSRCBRAF | |
| SCHEMBL6176508 | 0.88 | MAPK14 (0.52) | KDM4EMAPK14MAPTCSNK1DCSNK1E | |
| SCHEMBL6177339 | 0.85 | MAPK14 (0.53) | KDM4EMAPK14MAPTSRCBRAF | |
| SCHEMBL6178834 | 0.85 | MAPK14 (0.55) | KDM4EMAPK14MAPTSRCBRAF | |
| SCHEMBL6178427 | 0.84 | MAPK14 (0.51) | KDM4EMAPK14MAPTCSNK1DCSNK1E | |
| SCHEMBL6176783 | 0.83 | MAPK14 (0.50) | KDM4EMAPK14SRCBRAFKDR | |
| SCHEMBL6175417 | 0.83 | MAPK14 (0.49) | KDM4EMAPK14MAPTCSNK1DCSNK1E | |
| SCHEMBL4331477 | 0.82 | MAPK14 (0.51) | KDM4EMAPK14MAPTSRCBRAF | |
| SCHEMBL4330915 | 0.82 | MAPK14 (0.48) | KDM4EMAPK14SRCBRAFKDR | |
| SCHEMBL6177910 | 0.81 | MAPK14 (0.50) | KDM4EMAPK14SRCBRAFKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1142890-B1 | AMINOPYRAZOLE DERIVATIVES | TEIKOKU HORMONE MFG CO LTD (JP) | 2005-08-03 | — | — | EP | disclosed |
| US-6511997-B1 | For treatment of a disease associated with tumor necrosis factor alpha, interleukin 1, interleukin 6 or cyclooxygenase II; such as irritable bowel disease | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2003-01-28 | — | — | US | disclosed |
| EP-1142890-A1 | AMINOPYRAZOLE DERIVATIVES | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2001-10-10 | — | — | EP | disclosed |