Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 11/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.41 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6019372 | 0.85 | ECE1 (0.76) | ECE1 | |
| SCHEMBL8337542 | 0.82 | ECE1 (0.75) | ECE1 | |
| SCHEMBL6175488 | 0.81 | ECE1 (0.73) | ECE1 | |
| SCHEMBL6175232 | 0.78 | ECE1 (0.47) | ECE1 | |
| SCHEMBL6177288 | 0.75 | ECE1 (0.64) | ECE1 | |
| SCHEMBL6175560 | 0.75 | ECE1 (0.64) | ECE1 | |
| SCHEMBL6174737 | 0.73 | ECE1 (0.62) | ECE1 | |
| SCHEMBL8360497 | 0.73 | ECE1 (0.98) | ECE1 | |
| SCHEMBL6174552 | 0.73 | ECE1 (0.76) | ECE1 | |
| SCHEMBL6175629 | 0.72 | ECE1 (0.71) | ECE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432415-B1 | SUBSTITUTED 2,5-DIAMIDOINDOLES AS ECE INHIBITORS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES | BAYER HEALTHCARE AG (DE) | 2005-12-28 | — | — | EP | disclosed |