SCHEMBL6176769

SCHEMBL6176769

O=C(O)c1cccc2c(=O)cc(-c3cccc(OCc4ccc5ccccc5n4)c3)oc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CYSLTR1 Q9Y271 15/20 1.00
GPBAR1 Q8TDU6 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6176125 0.92 CYSLTR1 (1.00) CYSLTR1GPBAR1
SCHEMBL6175748 0.90 CYSLTR1 (1.00) CYSLTR1GPBAR1
SCHEMBL6175860 0.89 CYSLTR1 (0.80) CYSLTR1
SCHEMBL6175024 0.83 CYSLTR1 (0.71) CYSLTR1
SCHEMBL6177251 0.81 CYSLTR1 (0.81) CYSLTR1
SCHEMBL6175634 0.81 CYSLTR1 (0.79) CYSLTR1
SCHEMBL6175927 0.81 CYSLTR1 (1.00) CYSLTR1
SCHEMBL6175902 0.80 CYSLTR1 (1.00) CYSLTR1
SCHEMBL6177588 0.78 CYSLTR1 (1.00) CYSLTR1
SCHEMBL6174551 0.77 CYSLTR1 (1.00) CYSLTR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0834510-B1 Flavone derivative and medicine comprising the same KOWA CO (JP) 2005-02-23 EP disclosed
US-6136848-A ANTIALLERGENS; ASTHMA THERAPY KOWA CO., LTD. (JP) 2000-10-24 US disclosed
EP-0834510-A2 Flavone derivative and medicine comprising the same KOWA CO. LTD. (JP) 1998-04-08 EP disclosed