Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 11/20 | 0.52 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.45 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.44 |
| ▸ | CSNK1E | P49674 | 4/20 | 0.44 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 2/20 | 0.40 |
| ▸ | BRAF | P15056 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4330919 | 0.96 | MAPK14 (0.48) | MAPK14PTGDR2CSNK1DCSNK1ECSNK1A1 | |
| SCHEMBL6178643 | 0.96 | MAPK14 (0.48) | MAPK14PTGDR2CSNK1DCSNK1ECSNK1A1 | |
| SCHEMBL6178919 | 0.96 | MAPK14 (0.48) | MAPK14PTGDR2CSNK1DCSNK1ECSNK1A1 | |
| SCHEMBL6177527 | 0.95 | MAPK14 (0.53) | MAPK14PTGDR2CSNK1DCSNK1ECSNK1A1 | |
| SCHEMBL4338023 | 0.95 | MAPK14 (0.49) | MAPK14PTGDR2CSNK1DCSNK1ECSNK1A1 | |
| SCHEMBL6176467 | 0.93 | SRC (0.49) | MAPK14PTGDR2CSNK1DCSNK1ECSNK1A1 | |
| SCHEMBL6178366 | 0.92 | MAPK14 (0.44) | MAPK14PTGDR2CSNK1DCSNK1ECSNK1A1 | |
| SCHEMBL6177486 | 0.92 | SRC (0.51) | MAPK14PTGDR2CSNK1DCSNK1ECSNK1A1 | |
| SCHEMBL6176926 | 0.91 | MAPK14 (0.43) | MAPK14PTGDR2CSNK1DCSNK1EGRM5 | |
| SCHEMBL6178431 | 0.88 | MAPK14 (0.53) | MAPK14PTGDR2CSNK1DCSNK1ECSNK1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1142890-B1 | AMINOPYRAZOLE DERIVATIVES | TEIKOKU HORMONE MFG CO LTD (JP) | 2005-08-03 | — | — | EP | disclosed |
| US-6511997-B1 | For treatment of a disease associated with tumor necrosis factor alpha, interleukin 1, interleukin 6 or cyclooxygenase II; such as irritable bowel disease | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2003-01-28 | — | — | US | disclosed |
| EP-1142890-A1 | AMINOPYRAZOLE DERIVATIVES | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2001-10-10 | — | — | EP | disclosed |