Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 9/20 | 1.00 |
| ▸ | KDR | P35968 | 9/20 | 1.00 |
| ▸ | SRC | P12931 | 8/20 | 1.00 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.64 |
| ▸ | EGFR | P00533 | 2/20 | 0.63 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.63 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.63 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.63 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.63 |
| ▸ | RAF1 | P04049 | 1/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.54 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.54 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.54 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | CDK1 | P06493 | 1/20 | 0.48 |
| ▸ | CDK4 | P11802 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14833476 | 1.00 | BRAF (1.00) | BRAFKDRSRCMAPK14EGFR | |
| SCHEMBL14839391 | 0.86 | BRAF (1.00) | BRAFKDRSRCMAPK14EGFR | |
| SCHEMBL14839384 | 0.86 | BRAF (1.00) | BRAFKDRSRCMAPK14EGFR | |
| SCHEMBL14839387 | 0.85 | BRAF (1.00) | BRAFKDRSRCMAPK14EGFR | |
| SCHEMBL14839295 | 0.83 | BRAF (0.72) | BRAFKDRSRCMAPK14EGFR | |
| SCHEMBL14839244 | 0.83 | BRAF (1.00) | BRAFKDRSRCMAPK14EGFR | |
| SCHEMBL14839292 | 0.83 | BRAF (1.00) | BRAFKDRSRCMAPK14EGFR | |
| SCHEMBL10542264 | 0.82 | NPC1 (0.69) | BRAFKDRSRCEGFRNPC1 | |
| SCHEMBL16232219 | 0.81 | BRAF (1.00) | BRAFKDRSRCMAPK14EGFR | |
| SCHEMBL8547932 | 0.79 | BRAF (0.65) | BRAFKDRSRCMAPK14EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1326848-C | Aminopyrazole derivatives | TEIKOKU HORMONE MFG CO LTD (JP) | 2007-07-18 | — | — | CN | disclosed |
| EP-1142890-B1 | AMINOPYRAZOLE DERIVATIVES | TEIKOKU HORMONE MFG CO LTD (JP) | 2005-08-03 | — | — | EP | disclosed |
| US-6511997-B1 | For treatment of a disease associated with tumor necrosis factor alpha, interleukin 1, interleukin 6 or cyclooxygenase II; such as irritable bowel disease | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2003-01-28 | — | — | US | disclosed |
| CN-1331688-A | Aminopyridine Derivatives | TEIKOKU HORMONE MFG CO LTD (JP) | 2002-01-16 | — | — | CN | disclosed |
| EP-1142890-A1 | AMINOPYRAZOLE DERIVATIVES | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2001-10-10 | — | — | EP | disclosed |