Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 14/20 | 0.66 |
| ▸ | ABL1 | P00519 | 11/20 | 0.66 |
| ▸ | BCR | P11274 | 7/20 | 0.66 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.66 |
| ▸ | EGFR | P00533 | 3/20 | 0.66 |
| ▸ | PRKCA | P17252 | 3/20 | 0.66 |
| ▸ | KIT | P10721 | 6/20 | 0.63 |
| ▸ | KDR | P35968 | 2/20 | 0.62 |
| ▸ | LCK | P06239 | 1/20 | 0.59 |
| ▸ | LYN | P07948 | 1/20 | 0.59 |
| ▸ | FLT3 | P36888 | 1/20 | 0.59 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1929333 | 0.91 | ABL1 (0.65) | PDGFRAABL1BCRPDGFRBEGFR | |
| SCHEMBL1929917 | 0.91 | ABL1 (0.63) | PDGFRAABL1BCRPDGFRBEGFR | |
| SCHEMBL1929369 | 0.88 | PDGFRA (0.60) | PDGFRAABL1BCRPDGFRBEGFR | |
| SCHEMBL534165 | 0.88 | ABL1 (0.70) | PDGFRAABL1BCRPDGFRBEGFR | |
| SCHEMBL1927249 | 0.88 | PDGFRA (0.64) | PDGFRAABL1BCRPDGFRBEGFR | |
| SCHEMBL1927303 | 0.87 | PDGFRA (0.65) | PDGFRAABL1BCRPDGFRBEGFR | |
| SCHEMBL29707254 | 0.87 | ABL1 (0.71) | PDGFRAABL1BCRPDGFRBEGFR | |
| SCHEMBL533540 | 0.87 | ABL1 (0.71) | PDGFRAABL1BCRPDGFRBEGFR | |
| SCHEMBL1929347 | 0.87 | PDGFRA (0.63) | PDGFRAABL1BCRPDGFRBEGFR | |
| SCHEMBL1928330 | 0.87 | PDGFRA (0.68) | PDGFRAABL1BCRPDGFRBEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532138-A1 | INHIBITORS OF TYROSINE KINASES | Novartis AG (CH) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004005281-A1 | INHIBITORS OF TYROSINE KINASES | NOVARTIS AG (CH) | 2004-01-15 | — | — | WO | disclosed |