Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NAAA | Q02083 | 11/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | ASAH1 | Q13510 | 2/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8210416 | 1.00 | EPHX2 (0.47) | EPHX2GAANAAASCN9ANFKB1 | |
| SCHEMBL6176701 | 0.87 | EPHX2 (0.51) | EPHX2GAANAAANFKB1NFKB2 | |
| SCHEMBL4988872 | 0.87 | EPHX2 (0.47) | EPHX2GAANAAASCN9ANFKB1 | |
| SCHEMBL4988882 | 0.87 | EPHX2 (0.47) | EPHX2GAANAAASCN9ANFKB1 | |
| SCHEMBL30832132 | 0.86 | EPHX2 (0.47) | EPHX2GAANAAANFKB1NFKB2 | |
| SCHEMBL31656028 | 0.86 | EPHX2 (0.47) | EPHX2GAANAAANFKB1NFKB2 | |
| SCHEMBL645858 | 0.84 | EPHX2 (0.62) | EPHX2GAANAAASCN9ANFKB1 | |
| SCHEMBL949512 | 0.84 | EPHX2 (0.62) | EPHX2GAANAAASCN9ANFKB1 | |
| SCHEMBL3485516 | 0.84 | EPHX2 (0.62) | EPHX2GAANAAASCN9ANFKB1 | |
| SCHEMBL13878893 | 0.84 | GAA (0.45) | EPHX2GAANFKB1NFKB2RELA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0945445-B9 | 1,5-BENZODIAZEPINE DERIVATIVES | ZERIA PHARM CO LTD (JP) | 2005-12-28 | — | — | EP | disclosed |
| EP-0945445-B1 | 1,5-BENZODIAZEPINE DERIVATIVES | ZERIA PHARM CO LTD (JP) | 2003-09-03 | — | — | EP | disclosed |
| US-6239131-B1 | WHICH HAVE GASTRIN AND/OR CCK-B (CHOLECYSTOKININ-B) RECEPTOR ANTAGONISM, USEFUL AS REMEDIES FOR GASTRIC ULCER AND GASTROINTESTINAL MOVEMENT DISORDER. | ZERIA PHARMACEUTICAL CO., LTD. (JP) | 2001-05-29 | — | — | US | disclosed |
| EP-0945445-A1 | 1,5-BENZODIAZEPINE DERIVATIVES | ZERIA PHARMACEUTICAL CO., LTD. (JP) | 1999-09-29 | — | — | EP | disclosed |