Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 9/20 | 0.65 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 4/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6178434 | 0.89 | MAPK14 (0.67) | MAPK14RIPK3MAPK13MAPK12MAPK11 | |
| SCHEMBL6177632 | 0.88 | MAPK14 (0.66) | MAPK14RIPK3MAPK13MAPK12MAPK11 | |
| SCHEMBL6193980 | 0.88 | MAPK14 (0.63) | MAPK14RIPK3MAPK13MAPK12MAPK11 | |
| SCHEMBL6176683 | 0.88 | MAPK14 (0.65) | MAPK14RIPK3MAPK13MAPK12MAPK11 | |
| SCHEMBL6175326 | 0.88 | MAPK14 (0.65) | MAPK14RIPK3MAPK13MAPK12MAPK11 | |
| SCHEMBL6178135 | 0.87 | MAPK14 (0.64) | MAPK14RIPK3POLB | |
| SCHEMBL6176087 | 0.87 | MAPK14 (0.63) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL6180982 | 0.86 | MAPK14 (0.49) | MAPK14PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6178772 | 0.84 | MAPK14 (0.61) | MAPK14RIPK3MAPK13MAPK12MAPK11 | |
| Hydrochloric Acid SCHEMBL6177983 | 0.84 | MAPK14 (0.60) | MAPK14MAPK13MAPK12MAPK11ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1326848-C | Aminopyrazole derivatives | TEIKOKU HORMONE MFG CO LTD (JP) | 2007-07-18 | — | — | CN | disclosed |
| EP-1142890-B1 | AMINOPYRAZOLE DERIVATIVES | TEIKOKU HORMONE MFG CO LTD (JP) | 2005-08-03 | — | — | EP | disclosed |
| US-6511997-B1 | For treatment of a disease associated with tumor necrosis factor alpha, interleukin 1, interleukin 6 or cyclooxygenase II; such as irritable bowel disease | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2003-01-28 | — | — | US | disclosed |
| CN-1331688-A | Aminopyridine Derivatives | TEIKOKU HORMONE MFG CO LTD (JP) | 2002-01-16 | — | — | CN | disclosed |
| EP-1142890-A1 | AMINOPYRAZOLE DERIVATIVES | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2001-10-10 | — | — | EP | disclosed |