Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 10/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.44 |
| ▸ | CSNK1E | P49674 | 3/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4335755 | 0.90 | MAPK14 (0.54) | MAPK14KDM4ECSNK1DCSNK1EGRM5 | |
| SCHEMBL6179169 | 0.89 | MAPK14 (0.63) | MAPK14KDM4ECSNK1DCSNK1EGRM5 | |
| SCHEMBL6176832 | 0.89 | MAPK14 (0.63) | MAPK14KDM4ECSNK1DCSNK1EGRM5 | |
| SCHEMBL4336955 | 0.88 | MAPK14 (0.52) | MAPK14KDM4ECSNK1DCSNK1EPTGDR2 | |
| SCHEMBL7138225 | 0.87 | MAPK14 (0.55) | MAPK14KDM4ECSNK1DCSNK1EGRM5 | |
| SCHEMBL4343331 | 0.86 | MAPK14 (0.71) | MAPK14KDM4ECSNK1DCSNK1EMAPT | |
| SCHEMBL4337064 | 0.86 | MAPK14 (0.57) | MAPK14KDM4ECSNK1DCSNK1EGRM5 | |
| SCHEMBL6173798 | 0.86 | MAPK14 (0.42) | MAPK14KDM4ECSNK1DCSNK1EMAPT | |
| SCHEMBL6177420 | 0.86 | MAPK14 (0.57) | MAPK14KDM4ECSNK1DCSNK1EGRM5 | |
| SCHEMBL6177029 | 0.85 | MAPK14 (0.59) | MAPK14KDM4ECSNK1DCSNK1EGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1142890-B1 | AMINOPYRAZOLE DERIVATIVES | TEIKOKU HORMONE MFG CO LTD (JP) | 2005-08-03 | — | — | EP | disclosed |
| US-6511997-B1 | For treatment of a disease associated with tumor necrosis factor alpha, interleukin 1, interleukin 6 or cyclooxygenase II; such as irritable bowel disease | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2003-01-28 | — | — | US | disclosed |
| EP-1142890-A1 | AMINOPYRAZOLE DERIVATIVES | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2001-10-10 | — | — | EP | disclosed |