SCHEMBL6177798

SCHEMBL6177798

CC1(Cc2ccnc(NC(N)=O)c2)NC(=O)N(c2ccc(SC(F)(F)F)cc2)C1=O

nearest known ligand 0.57

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
IGF1R P08069 19/20 0.57
NR3C2 P08235 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6177168 0.88 IGF1R (0.56) IGF1R
SCHEMBL6174759 0.88 IGF1R (0.54) IGF1R
SCHEMBL6175271 0.88 IGF1R (0.53) IGF1R
SCHEMBL6176012 0.88 IGF1R (0.53) IGF1R
SCHEMBL6173969 0.88 IGF1R (0.55) IGF1R
SCHEMBL6175913 0.87 IGF1R (0.54) IGF1R
SCHEMBL6175090 0.86 IGF1R (0.54) IGF1R
SCHEMBL6174747 0.86 IGF1R (0.57) IGF1R
SCHEMBL6173795 0.86 IGF1R (0.67) IGF1R
SCHEMBL6173762 0.85 IGF1R (0.54) IGF1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1599464-A2 NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS Aventis Pharma S.A. (FR) 2005-11-30 EP disclosed
WO-2004070050-A2 CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS AVENTIS PHARMA S.A. (FR) 2004-08-19 WO disclosed